產品中心/ products

      您的位置:首頁  -  產品中心  -  天然產物  -  天然產物對照品標準品  -  佛司可林Forskolin(Colforsin)

      佛司可林Forskolin(Colforsin)

      • 產品型號:
      • 更新時間:2016-08-18

      簡要描述:Forskolin(Colforsin) CAS:66575-29-9 佛司可林Forskolin(Colforsin)
      Appearance:Off-white to white powder
      Assay(HPLC):>98%

      產品詳情

      Forskolin(Colforsin) CAS:66575-29-9  佛司可林Forskolin(Colforsin) 

      Appearance:Off-white to white powder

      Assay(HPLC):>98%

      Product Name: Forskolin

      CAS No.: 66575-29-9

      Synonyms: Colforsin; ForsLean; Coleonol; HL 362; L 75-1362B; NSC 357088; NSC 375489; 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one

       Chemical Name: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-1H-Naphtho[2,1-b]pyran-1-one

      Source: From Coleus Forskohlii

      Molecular Formula: C22H34O7

      Molecular Weight: 410.50

      Appearance: Off-white to white powder

      Assay(HPLC)≥98%

      Biological Activity: Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules. Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP.

       

       Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals. Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.

       The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.

       

       An adenylate cyclase activator and MAP kinase inhibitor. Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, plaet anti-aggregatory and anti-hypertensive effects. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR.

       Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii. Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.Forskolin effects calcium currents and inhibits MAP kinase.

      在線咨詢

      留言框

      • 產品:

      • 您的單位:

      • 您的姓名:

      • 聯系電話:

      • 常用郵箱:

      • 省份:

      • 詳細地址:

      • 補充說明:

      • 驗證碼:

        請輸入計算結果(填寫阿拉伯數字),如:三加四=7
      公司簡介  >  在線留言  >  聯系我們  >  
      產品中心
      天然產物

      CONTACT

      辦公地址:中國(上海)自由貿易試驗區臨港新片區新楊公路1666號3幢315室 EMAIL:2885066715@qq.com
      掃碼關注公眾號
      版權所有©2025 凱立德生物醫藥技術(上海)有限公司 All Rights Reserved   備案號:滬ICP備15046197號-1   sitemap.xml技術支持:化工儀器網   管理登陸

      TEL:021-58180488

      掃碼關注公眾號
      主站蜘蛛池模板: 怡红院AV一区二区三区| 无码日韩人妻AV一区免费l| 国产拳头交一区二区| 中文字幕一区二区三区永久| 国产午夜精品片一区二区三区| 日本精品夜色视频一区二区| 久久毛片一区二区| 国产婷婷色一区二区三区| 又紧又大又爽精品一区二区| 久久精品国产一区二区三| 一区二区视频免费观看| 中文字幕日韩欧美一区二区三区 | 日本不卡一区二区三区视频| 亚洲AV无码一区二区三区牲色| 一区二区三区日韩| 91久久精品一区二区| 国产精品一区二区三区99| 国产91大片精品一区在线观看| 国产一区二区三区久久| 夜夜精品无码一区二区三区| 日本免费一区二区三区最新| 亚洲AV噜噜一区二区三区| 亚洲A∨无码一区二区三区| 538国产精品一区二区在线| 成人精品一区二区电影| 亚洲日韩一区精品射精| 亚洲日韩AV一区二区三区四区| 日韩av无码一区二区三区| 亚洲视频在线一区| 欧洲无码一区二区三区在线观看 | 无码人妻精品一区二| 国产精品福利区一区二区三区四区| 久久精品无码一区二区三区免费| 国产福利微拍精品一区二区| 人妻aⅴ无码一区二区三区| 不卡一区二区在线| 精品国产一区二区三区久久影院| 制服美女视频一区| 精品一区二区AV天堂| 波多野结衣av高清一区二区三区| 日韩在线视频一区|